Granzymes at a glance.

نویسندگان

Michael Bots

Jan Paul Medema

چکیده

Defence against virally infected and malignant cells depends on the action of cytotoxic T lymphocytes and natural killer cells (Barry and Bleackley, 2002; Russell and Ley, 2002). Although these use several mechanisms to eliminate target cells, the principal event is secretion of cytotoxic granules. These granules contain the pore-forming protein perforin together with a variety of granule-associated proteases, which include the granzymes. Target cell recognition by cytotoxic lymphocytes induces secretion of the cytotoxic granular content towards the target and the induction of death. Here, we briefly provide a generalized view of granzyme signalling and the substrates involved.

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